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Review
Nature Genetics  21, 48 - 50 (1999)
doi:10.1038/4475

DNA microarrays in drug discovery and development

Christine Debouck1 & Peter N. Goodfellow2

1  SmithKline Beecham Pharmaceuticals. 709 Swedeland Road, King of Prussia, Pennsylvania 19406, USA.

2  SmithKline Beecham Pharmaceuticals. New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK.

DNA microarrays can be used to measure the expression patterns of thousands of genes in parallel, generating clues to gene function that can help to identify appropriate targets for therapeutic intervention. They can also be used to monitor changes in gene expression in response to drug treatments. Here, we discuss the different ways in which microarray analysis is likely to affect drug discovery.

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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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