Nature Genetics
21, 38 - 41 (1999)
doi:10.1038/4466
The genetics of cancer—a 3D modelKristina A. Cole1, 2, David B. Krizman3
& Michael R. Emmert−Buck1, 31
Pathogenetics Unit, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA. 2
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. 3
Cancer Genome Anatomy Project, Office of the Director, National Cancer Institute, Bethesda, Maryland 20892, USA. mbuck@helix.nih.gov
Gene expression microarrays hold great promise for studies of human
disease states. There are significant technical issues specific to utilizing
clinical tissue samples which have yet to be rigorously addressed and completely
overcome. Precise, quantitative measurement of gene expression profiles from
specific cell populations is at hand, offering the scientific community the
first comprehensive view of the in vivo molecular anatomy of normal
cells and their diseased counterparts. Here, we propose a model for integrating—in
three dimensions—expression data obtained using the microarray.
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