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Letter

Nature Genetics 17, 350–352 (1 November 1997) | doi:10.1038/ng1197-350

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele

Simon T. Bennett , Amanda J. Wilson , Laura Esposito , Nourdine Bouzekri , Dag E. Undlien , Francesco Cucca , Lorenza Nistic|[ograve]| , Raffaella Buzzetti , , Emanuele Bosi , Flemming Pociot , J|[oslash]|rn Nerup , Anne Cambon-Thomsen , Alberto Pugliese , Julian P.H. Shield , Patricia A. McKinney , Stephen C. Bain , Constantin Polychronakos & John A. Todd

The IDDM2 type 1 diabetes susceptibility locus was mapped to1–6 and identified as7 allelic variation at the insulin gene (INS) VNTR regulatory polymorphism. In Caucasians, INS VNTR alleles divide into two discrete size classes1.