Nature Genetics
17, 335 - 337 (1997)
doi:10.1038/ng1197-335
Quantitative trait loci analysis affecting contextual conditioning in miceBarbara Caldarone1, 2, Carlos Saavedra1, 2, Kathleen Tartaglia1, 2, Jeanne M Wehner3, Bruce C Dudek1
& Lorraine Flaherty1, 2, 3, 4
1Departments of Psychology and Biomedical Sciences, University at Albany, State University of New York, Albany, New York 12222, USA.
2Molecular Genetics Program, Wadsworth Center, Albany, New York, 12201-2002 USA.
3The Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA.
4e-mail: flaherty@wadsworth.org In an extensive backcross of mice between C3H/HeJ (C3H) and C57BL/6J (B6), we sought to map genes that influence learning and memory as measured by performance in a contextual fear-conditioning paradigm. Our results indicate that there are several genetic regions that have a strong influence on performance in this paradigm. The strongest influences map to the proximal and distal ends of chromosome 1 (lod scores of 5.14 and 4.76, respectively). Other chromosomal regions (chromosomes 3, 7, 8, 9 and 18) were also identified as candidates for regions containing genes influencing contextual fear conditioning, with lod scores ranging from 1.8 to 2.7.
REFERENCES
- Bourtchuladze, R. et al. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell. 79, 59–68 (1994). | Article | PubMed | ISI | ChemPort |
- Silva, A.J. et al. Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning. Cold Spring Harbor Symp. Quant. Biol. 57, 527–539 (1992). | PubMed | ISI | ChemPort |
- Silva, A.J. et al. Impaired learning in mice with abnormal short-lived plasticity. Curr. Biol. 6, 1509–1518 (1996). | PubMed | ISI | ChemPort |
- Aiba, A. et al. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell. 79, 365–375 (1994). | Article | PubMed | ISI | ChemPort |
- Kim, J.J. & Fanselow, M.S. Modality-specific retrograde amnesia of fear. Science. 256, 675–677 (1992). | ChemPort |
- Phillips, R.G. & LeDoux, J.E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106, 274–285 (1992). | Article | PubMed | ISI | ChemPort |
- Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241–247 (1995). | Article | PubMed | ISI | ChemPort |
- Lander, E.S. & Botstein, D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 121, 185–199 (1989). | PubMed | ISI | ChemPort |
- Flint, J. et al. A simple genetic basis for a complex psychological trait in laboratorymice. Science. 269, 1432–1435 (1995). | PubMed | ISI | ChemPort |
- Tarricone, B.J., Hingtgen, J.N., Belknap, J.K., Mitchell, S.R. & Nurnberger, J.I.,Jr., Quantitative trait loci associated with the behavioral response of BXD recombinant inbred mice to restraint stress: a preliminary communication. Behav. Genet. 25, 489–495 (1995). | PubMed | ISI | ChemPort |
- Wehner, J.M. et al. Quantitative trait loci analysis of contextual fear conditioning in mice. Nature Genet. 17, 331–334 (1997). | Article | PubMed | ISI | ChemPort |
- Paylor, R., Tracy, R., Wehner, J. & Rudy, J.W. DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning. Behav.Neurosci. 108, 810–817 (1994). | ChemPort |
- Paterson, A.M. et al. Resolution of quantitative traits into Mendelian factors using a complete linkage map of restriction fragment length polymorphisms.. Nature. 335, 721–726 (1988). | Article | PubMed | ISI | ChemPort |
- Laird, P.W. et al. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293 (1991). | PubMed | ISI | ChemPort |
- Dietrich, W. et al. A genetic map of the mouse suitable for typing intraspecific crosses. Genetics. 131, 423–447 (1992). | PubMed | ISI | ChemPort |
- Dietrich, W. et al. A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genet. 7, 220–245 (1994). | Article | PubMed | ISI | ChemPort |
|
