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Letter
Nature Genetics 15, 181–185 (1 February 1997) | doi:10.1038/ng0297-181
Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements
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Abstract
Genomic imprinting is an epigenetic chromosomal modification in the gamete or zygote causing preferential expression of a specific parental allele in somatic cells of the offspring. We and others have identified three imprinted human genes on 11p15.5, IGF2 (refs 1-4), H19 (refs 1,5), and p57KIP2 (ref.
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