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Nature Genetics 15, 146–156 (1 February 1997) | doi:10.1038/ng0297-146

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

Michael J. Mendez , Larry L. Green , Jose R.F. Corvalan , Xiao-Chi Jia , Catherine E. Maynard-Currie , Xiao-dong Yang , Michael L. Gallo , Donna M. Louie , Doris V. Lee , Karen L. Erickson , Jac Luna , Catherine M.-N. Roy , Hadi Abderrahim , Ford Kirschenbaum , Masato Noguchi , Douglas H. Smith , Atsushi Fukushima , Joanna F. Hales , Mitchell H. Finer , C. Geoffrey Davis , Krisztina M. Zsebo & Aya Jakobovits