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Letter
Nature Genetics 15, 106–110 (1 January 1997) | doi:10.1038/ng0197-106
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
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Abstract
The homeodomain protein IPF1 (also known as IDX1, STF1 and PDX1; see Methods) is critical for development of the pancreas in mice and is a key factor for the regulation of the insulin gene in the β-cells of the endocrine pancreas1–6. Targeted disruption of the Ipf1 gene encoding IPF1 in transgenic mice results in a failure of the pancreas to develop (pancreatic agenesis)4–7.
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