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Letter

Nature Genetics 15, 103–105 (1 January 1997) | doi:10.1038/ng0197-103

Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene

Simon A. Gayther , Jonathon Mangion , Paul Russell , Sheila Seal , Rita Barfoot , Bruce A.J. Ponder , Michael R. Stratton & Douglas Easton

The breast cancer susceptibility gene BRCA2 on chromosome 13q12–13 has recently been identified1. Germline mutations of BRCA2 are predicted to account for approximately 35% of families with multiple case, early onset female breast cancer, and they are also associated with an increased risk of male breast cancer, ovarian cancer, prostate cancer and pancreatic cancer2–4.