Nature Genetics
13, 154 - 160 (1996)
doi:10.1038/ng0696-154
Minisatellite diversity supports a recent African origin for modern humansJohn A.L. Armour1, 5, Tiiu Anttinen2, Celia A. May1, Emilce E. Vega1, Antti Sajantila2, Judith R. Kidd3, Kenneth K. Kidd3, Jaume Bertranpetit4, Svante Pääbo2
& Alec J. Jeffreys1
1Department of Genetics, University a/Leicester, University Road, Leicester LE1 7RH, UK
2Zoologisches Institutder Universitat Munchen, P.O. Box 2021 36, D-80021 München, Germany
3Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520-8005, USA
4Laborator d'Antropologia, Facultat de Biologia, Universitat de Barcelona, Av Diagonal 645, E-08028 Barcelona, Spain.E.E.V. current address: Institute of Molecular Medicine, John Raddiffe Hospital, Headington, Oxford OX39DU,UK.
5Department of Genetics, University ofNottingham, Queen's Medical Centre, Nottingham NG72UH, UK Correspondence should be addressed to J.A.L.A. In a study of human diversity at a highly variable locus, we have mapped the internal structures of tandem−repetitive alleles from different populations at the minisatellite MS205 (D76S309).The results give an unusually detailed view of the different allelic structures represented on modern human chromosomes, and of the ancestral relationships between them. There was a clear difference in allelic diversity between African and non−African populations. A restricted set of allele families was found in non−African populations, and formed a subset of the much greater diversity seen on African chromosomes. The data strongly support a recent African origin for modern human diversity at this locus.
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