Nature Genetics
13, 147 - 153 (1996)
doi:10.1038/ng0696-147
Identification of sex−specific quantitative trait loci controlling alcohol preference in C57BL/6 miceJustine A. Melo1, Jay Shendure1, Kara Pociask1
& Lee M. Silver1
1Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA Correspondence should be addressed to L.M.S. Mice from various inbred strains consume alcoholic beverages at highly reproducible and strain−specific levels. While most mice consume alcohol in moderate amounts, C57BL/6J animals exhibit sustained oral ingestion of high levels of alcohol in the presence of competing water and food. We now report a genetic investigation of this phenotype as one potential model for alcoholism. An intercross−backcross breeding protocol was used to identify two recessive alcohol preference quantitative trait loci (QTLs) that are both sex−restricted in expression. A comparison of our results with those of an earlier morphine preference study argues against the hypothesis of a single unified phenotype defined by a preference for all euphoria−producing drugs.
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