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Letter

Nature Genetics 12, 333–337 (1 March 1996) | doi:10.1038/ng0396-333

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

S.V. Tavtigian , J. Simard , J. Rommens , F. Couch , D. Shattuck-Eidens , S. Neuhausen , S. Merajver , S. Thorlacius , K. Offit , D. Stoppa-Lyonnet , C. Belanger , R. Bell , S. Berry , R. Bogden , Q. Chen , T. Davis , M. Dumont , C. Frye , T. Hattier , S. Jammulapati , T. Janecki , P. Jiang , R. Kehrer , J.-F. Leblanc , J.T. Mitchell , J. McArthur-Morrison , K. Nguyen , Y. Peng , C. Samson , M. Schroeder , S.C. Snyder , L. Steele , M. Stringfellow , C. Stroup , B. Swedlund , J. Swense , D. Teng , A. Thomas , T. Tran , M. Tranchant , J. Weaver-Feldhaus , A.K.C. Wong , H. Shizuya , J.E. Eyfjord , L. Cannon-Albright , M. Tranchant , F. Labrie , M.H. Skolnick , B. Weber , A. Kamb & D.E. Goldgar

Breast carcinoma is the most common malignancy among women in developed countries. Because family history remains the strongest single predictor of breast cancer risk, attention has focused on the role of highly penetrant, dominantly inherited genes in cancer-prone kindreds1.