Nature Genetics
12, 31 - 37 (1996)
doi:10.1038/ng0196-31
Genetic analysis of non-insulin dependent diabetes mellitus in the GK ratJoakim Galli1, Luo-Sheng Li1, Anna Glaser1, Claes-Göran Östenson1, Hong Jiao1, Hossein Fakhrai-Rad1, Howard J. Jacob2, Eric S. Lander3, 4
& Holger Luthman1, 5
1Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Hospital, L602, S−17176 Stockholm, Sweden.
2Cardiovascular Research Center, Massachusetts General Hospital, Charkstown Massachusetts 02129, USA.
3Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.
4Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
5Correspondence should be addressed to H.L. Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases. REFERENCES
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