Nature Genetics
11, 248 - 256 (1995)
doi:10.1038/ng1195-248
Linkage between sexual orientation and chromosome Xq28 in males but not in femalesStella Hu1, Angela M. L. Pattatucci1, Chavis Patterson1, Lin Li1, David W. Fulker2, Stacey S. Cherny2, Leonid Kruglyak3
& Dean H. Hamer1
1Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
2Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
3Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02139, USA Correpsondence should be addressed to D.H.H. We have extended our analysis of the role of the long arm of the X chromosome (Xq28) in sexual orientation by DNA linkage analyses of two newly ascertained series of families that contained either two gay brothers or two lesbian sisters as well as heterosexual siblings. Linkage between the Xq28 markers and sexual orientation was detected for the gay male families but not for the lesbian families or for families that failed to meet defined inclusion criteria for the study of sex−linked sexual orientation. Our results corroborate the previously reported linkage between Xq28 and male homosexuality in selected kinships and suggest that this region contains a locus that influences individual variations in sexual orientation in men but not in women.
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