Abstract
Sry is the Y-chromosomal gene that is pivotal in the determination of sex in mammals1–3, however the structure of the Sry transcript produced in the embryo has not been determined. We show here that the transcript expressed in the developing mouse gonad at the sex determining stage of development is linear, polyadenylated and encoded byasingleexon, incontrasttothecircular, apparently untranslated transcript produced in adult testes4. The linear transcript was not detected in any other fetal tissue nor in any adult tissue tested, and was expressed only in the genital ridge portion of the urogenital ridge. The spatial and temporal profile of Sry expression suggests that its role in the mouse fetus is limited to initiating Sertoli cell development during testis determination.
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Jeske, Y., Bowles, J., Greenfield, A. et al. Expression of a linear Sry transcript in the mouse genital ridge. Nat Genet 10, 480–482 (1995). https://doi.org/10.1038/ng0895-480
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DOI: https://doi.org/10.1038/ng0895-480
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