Nature Genetics
10, 436 - 444 (1995)
doi:10.1038/ng0895-436
Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumoursEric F.P.M. Schoenmakers1, Sylke Wanschura2, Raf Mols1, Jörn Bullerdiek2, Herman Van den Berghe1
& Wim J.M. Van de Ven1
1Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven, and Flanders Institute for Biotechnology, Herestraat 49, B-3000 Leuven, Belgium
2Center for Human Genetics, University of Bremen, Leobenerstrasse ZHG, D-28359 Bremen, Germany Correspondence should be addressed to W.J.M.V.d.V. We recently showed that the 1.7 megabase multiple aberration region (MAR) on human chromosome 12q15 harbours recurrent breakpoints frequently found in a variety of benign solid tumours. We now report a candidate gene within MAR suspected to be of pathogenetical relevance. Using positional cloning, we have identified the high mobility group protein gene HMGI−C within a 175 kilobase segment of MAR and characterized its genomic organization. By FISH analysis, we show the majority of the breakpoints of eight different benign solid tumour types fall within this gene. By Southern blot and 3'−RACE analysis, we demonstrate consistent rearrangements in HMGI−C and/or expression of altered HMGI−C transcripts. These results suggest a link between a member of the HMG gene family and benign solid tumour development.
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