Nature Genetics
10, 261 - 268 (1995)
doi:10.1038/ng0795-261
Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiaeYasufumi Murakami1, Masanori Naitou1, Hiroko Hagiwara1, 2, Takehiko Shibata2, 3, Masashi Ozawa1, Syun-ichi Sasanuma1, Motoe Sasanuma1, Yukari Tsuchiya1, Eiichi Soeda5, Kazushige Yokoyama5, Masaaki Yamazaki4, Hiroyuki Tashiro4
& Toshihiko Eki1
1Division of Human Genome Research, Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN), 3-1-1 Koyadai, Tsukuba, Ibaraki 305, Japan
2Graduate School of Science and Engineering, Saitama University, 255 Shimo-okubo, Urawa, Saitama 338, Japan
3Biodesign Research Group, The Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako, Saitama 351-01, Japan
4Bioscience Research Laboratory, Fujiya, Co., 228 Soya, Hatano, Kanagawa 257, Japan
5Gene Bank, Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN), 3-1-1 Koyadai, Tsukuba, Ibaraki 305, Japan Correspondence should be addressed to Y.M. The complete nucleotide sequence of Saccharomyces cerevisiae chromosome VI (270 kb) has revealed that it contains 129 predicted or known genes (300 bp or longer). Thirty−seven (28%) of which have been identified previously. Among the 92 novel genes, 39 are highly homologous to previously identified genes. Local sequence motifs were compared to active ARS regions and inactive loci with perfect ARS core sequences to examine the relationship between these motifs and ARS activity. Additional ARS sequences were predominantly observed in 3' flanking sequences of active ARS loci.
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