Nature Genetics
10, 202 - 207 (1995)
doi:10.1038/ng0695-202
Mapping of the congenital generalized hypertrichosis locus to chromosome Xq24−q27.1Luis E. Figuera1, 2, Massimo Pandolfo1, 3, Patrick W. Dunne1, Jose M. Cantú2
& Pragna I. Patel1, 4, 5
1Departments of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
2División de Genética, CIBO-IMSS and CUCS, Universidad de Guadalajara, Guadalajara, Jal., México
3Division of Biochemistry and Genetics, Istituto Nazionale Neurologico Besta, Milan, Italy
4Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
5Departments of Human Genome Center, Baylor College of Medicine, Houston, Texas 77030, USA Correspondence should be addressed to P.I.P. Congenital generalized hypertrichosis (CGH) is a rare, fully penetrant X−linked dominant trait previously described in a single, multigenerational Mexican family. CGH is a visually striking phenotype characterized by excessive facial and upper torso hair in males and by less severe asymmetric hairiness in females. We have found significant evidence for linkage with several markers from the long arm of the X chromosome. Recombinant chromosomes place the CGH gene within a 22 cM interval between DXS425 and DXS1227 in Xq24−Xq27.1. The localization of a gene for CGH represents the first step towards the isolation of genes involved in hair growth pattern, particularly those involved in restriction of areas in humans.
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