Rice cheerleaders by K. Wing and E. Dewalt

Genomes of 13 domesticated and wild rice relatives highlight genetic conservation, turnover and innovation across the genus Oryza

Latest Research

  • Article |

    The authors report that DNA methylation coevolves with the DNA alkylation repair enzyme ALKB2 across eukaryotes. They also show that DNA methyltransferases cause alkylation damage in vitro and in vivo by introducing 3-methylcytosine into DNA.

    • Silvana Rošić
    • , Rachel Amouroux
    • , Cristina E. Requena
    • , Ana Gomes
    • , Max Emperle
    • , Toni Beltran
    • , Jayant K. Rane
    • , Sarah Linnett
    • , Murray E. Selkirk
    • , Philipp H. Schiffer
    • , Allison J. Bancroft
    • , Richard K. Grencis
    • , Albert Jeltsch
    • , Petra Hajkova
    •  & Peter Sarkies
  • Article |

    The authors report a data-driven approach to phenotyping 3D facial shape. They apply their methodology to 2,329 individuals of European ancestry and identify 38 loci that associate with specific facial morphologies, some of which overlap with neural-crest-specific regulatory regions.

    • Peter Claes
    • , Jasmien Roosenboom
    • , Julie D. White
    • , Tomek Swigut
    • , Dzemila Sero
    • , Jiarui Li
    • , Myoung Keun Lee
    • , Arslan Zaidi
    • , Brooke C. Mattern
    • , Corey Liebowitz
    • , Laurel Pearson
    • , Tomás González
    • , Elizabeth J. Leslie
    • , Jenna C. Carlson
    • , Ekaterina Orlova
    • , Paul Suetens
    • , Dirk Vandermeulen
    • , Eleanor Feingold
    • , Mary L. Marazita
    • , John R. Shaffer
    • , Joanna Wysocka
    • , Mark D. Shriver
    •  & Seth M. Weinberg
  • Article |

    The authors find that, in a high-fat diet (HFD) mouse model, levels of Stella protein are reduced in oocytes, leading to abnormal epigenetic patterning during development and to embryonic growth defects. Overexpression of Stella in oocytes from HFD-fed mice partially ameliorates developmental defects.

    • Longsen Han
    • , Chao Ren
    • , Ling Li
    • , Xiaoyan Li
    • , Juan Ge
    • , Haichao Wang
    • , Yi-Liang Miao
    • , Xuejiang Guo
    • , Kelle H. Moley
    • , Qiang Wang
    •  & Wenjie Shu
  • Letter |

    Meta-analysis of data from 58,265 cattle shows that the genetic architecture underlying stature is similar to that in humans, where many genomic regions individually explain only a small amount of phenotypic variance.

    • Aniek C. Bouwman
    • , Hans D. Daetwyler
    • , Amanda J. Chamberlain
    • , Carla Hurtado Ponce
    • , Mehdi Sargolzaei
    • , Flavio S. Schenkel
    • , Goutam Sahana
    • , Armelle Govignon-Gion
    • , Simon Boitard
    • , Marlies Dolezal
    • , Hubert Pausch
    • , Rasmus F. Brøndum
    • , Phil J. Bowman
    • , Bo Thomsen
    • , Bernt Guldbrandtsen
    • , Mogens S. Lund
    • , Bertrand Servin
    • , Dorian J. Garrick
    • , James Reecy
    • , Johanna Vilkki
    • , Alessandro Bagnato
    • , Min Wang
    • , Jesse L. Hoff
    • , Robert D. Schnabel
    • , Jeremy F. Taylor
    • , Anna A. E. Vinkhuyzen
    • , Frank Panitz
    • , Christian Bendixen
    • , Lars-Erik Holm
    • , Birgit Gredler
    • , Chris Hozé
    • , Mekki Boussaha
    • , Marie-Pierre Sanchez
    • , Dominique Rocha
    • , Aurelien Capitan
    • , Thierry Tribout
    • , Anne Barbat
    • , Pascal Croiseau
    • , Cord Drögemüller
    • , Vidhya Jagannathan
    • , Christy Vander Jagt
    • , John J. Crowley
    • , Anna Bieber
    • , Deirdre C. Purfield
    • , Donagh P. Berry
    • , Reiner Emmerling
    • , Kay-Uwe Götz
    • , Mirjam Frischknecht
    • , Ingolf Russ
    • , Johann Sölkner
    • , Curtis P. Van Tassell
    • , Ruedi Fries
    • , Paul Stothard
    • , Roel F. Veerkamp
    • , Didier Boichard
    • , Mike E. Goddard
    •  & Ben J. Hayes
  • Letter |

    Identification of AvrStb6, the fungal avirulence effector that triggers Stb6-mediated resistance in wheat, here demonstrates that neither host resistance nor fungicide treatment suppresses fungal sexual reproduction, thus unveiling implications of fungal sex in plant disease control.

    • Gerrit H. J. Kema
    • , Amir Mirzadi Gohari
    • , Lamia Aouini
    • , Hesham A. Y. Gibriel
    • , Sarah B. Ware
    • , Frank van den Bosch
    • , Robbie Manning-Smith
    • , Vasthi Alonso-Chavez
    • , Joe Helps
    • , Sarrah Ben M’Barek
    • , Rahim Mehrabi
    • , Caucasella Diaz-Trujillo
    • , Elham Zamani
    • , Henk J. Schouten
    • , Theo A. J. van der Lee
    • , Cees Waalwijk
    • , Maarten A. de Waard
    • , Pierre J. G. M. de Wit
    • , Els C. P. Verstappen
    • , Bart P. H. J. Thomma
    • , Harold J. G. Meijer
    •  & Michael F. Seidl

News & Comment

  • Editorial |

    The reconstruction of the genome of a woman of African ancestry from her European descendants, across eight generations, connects living people to a documented saga, drawing attention to the individuals who participated in historic events at a time when the legal, cultural and ethical implications of individual human rights began to gain currency. It is also a technical achievement that extends the methodologies for understanding our interwoven genomic and social histories.

  • News & Views |

    New genomic analyses indicate that pioneer transcription factors can sample a diverse repertoire of common binding sites among different cell types and become enriched where they cooperate with other factors specific to each cell. Pioneer-factor binding is mechanistically separate from, and is necessary for, subsequent phenomena of chromatin opening and epigenetic memory in vivo.

    • Kenneth S. Zaret
  • News & Views |

    Two new studies identify rare homozygous variants in ADCY3 that are causal for monogenic obesity in consanguineous families of Pakistani origin and are associated with increased risk of obesity in Greenlandic individuals. Greenlandic carriers of homozygous loss-of-function variants in ADCY3, and individuals from trans-ancestry studies with a burden of rare ADCY3 loss-of-function variants, also have increased risk of type 2 diabetes.

    • Inês Barroso
  • News & Views |

    Dysregulated lipid metabolism is a prominent feature of prostate cancers. Two papers in this issue identify novel genomic drivers of lipid metabolism in prostate cancer and provide implications for the subtyping and treatment of the disease.

    • Ninu Poulose
    • , Francesca Amoroso
    • , Rebecca E. Steele
    • , Reema Singh
    • , Chee Wee Ong
    •  & Ian G. Mills
  • News & Views |

    H3K4me1 is enriched at active and primed enhancers. However, whether H3K4me1 controls or simply correlates with enhancer activity and function has remained unclear. Several recent reports, including two in Nature Genetics, provide major mechanistic and functional insights into the role of H3K4me1 at enhancers.

    • Alvaro Rada-Iglesias

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