Rice cheerleaders by K. Wing and E. Dewalt

Genomes of 13 domesticated and wild rice relatives highlight genetic conservation, turnover and innovation across the genus Oryza

Latest Research

  • Letter |

    Identification of AvrStb6, the fungal avirulence effector that triggers Stb6-mediated resistance in wheat, here demonstrates that neither host resistance nor fungicide treatment suppresses fungal sexual reproduction, thus unveiling implications of fungal sex in plant disease control.

    • Gerrit H. J. Kema
    • , Amir Mirzadi Gohari
    • , Lamia Aouini
    • , Hesham A. Y. Gibriel
    • , Sarah B. Ware
    • , Frank van den Bosch
    • , Robbie Manning-Smith
    • , Vasthi Alonso-Chavez
    • , Joe Helps
    • , Sarrah Ben M’Barek
    • , Rahim Mehrabi
    • , Caucasella Diaz-Trujillo
    • , Elham Zamani
    • , Henk J. Schouten
    • , Theo A. J. van der Lee
    • , Cees Waalwijk
    • , Maarten A. de Waard
    • , Pierre J. G. M. de Wit
    • , Els C. P. Verstappen
    • , Bart P. H. J. Thomma
    • , Harold J. G. Meijer
    •  & Michael F. Seidl
  • Letter |

    The authors report map-based cloning of the wheat Stb6 gene, which encodes a conserved wall-associated receptor kinase (WAK)-like protein. Stb6 confers gene-for-gene disease resistance to fungal pathogen Zymoseptoria tritici by recognition of a matching pathogen effector.

    • Cyrille Saintenac
    • , Wing-Sham Lee
    • , Florence Cambon
    • , Jason J. Rudd
    • , Robert C. King
    • , William Marande
    • , Stephen J. Powers
    • , Hélène Bergès
    • , Andy L. Phillips
    • , Cristobal Uauy
    • , Kim E. Hammond-Kosack
    • , Thierry Langin
    •  & Kostya Kanyuka
  • Letter |

    Whole-exome sequencing identifies mutations in CLCN2 in individuals with familial hyperaldosteronism type II or early-onset primary aldosteronism. These gain-of-function mutations cause chloride channel opening and glomerulosa cell depolarization, showing a role for anion channels in aldosterone production.

    • Ute I. Scholl
    • , Gabriel Stölting
    • , Julia Schewe
    • , Anne Thiel
    • , Hua Tan
    • , Carol Nelson-Williams
    • , Alfred A. Vichot
    • , Sheng Chih Jin
    • , Erin Loring
    • , Verena Untiet
    • , Taekyeong Yoo
    • , Jungmin Choi
    • , Shengxin Xu
    • , Aihua Wu
    • , Marieluise Kirchner
    • , Philipp Mertins
    • , Lars C. Rump
    • , Ali Mirza Onder
    • , Cory Gamble
    • , Daniel McKenney
    • , Robert W. Lash
    • , Deborah P. Jones
    • , Gary Chune
    • , Priscila Gagliardi
    • , Murim Choi
    • , Richard Gordon
    • , Michael Stowasser
    • , Christoph Fahlke
    •  & Richard P. Lifton
  • Letter |

    A gain-of-function mutation in the CLCN2 chloride channel gene (encoding ClC-2) causes primary aldosteronism. The mutation abolishes voltage-dependent gating of ClC-2, highlighting a role for chloride conduction in regulating aldosterone biosynthesis.

    • Fabio L. Fernandes-Rosa
    • , Georgios Daniil
    • , Ian J. Orozco
    • , Corinna Göppner
    • , Rami El Zein
    • , Vandana Jain
    • , Sheerazed Boulkroun
    • , Xavier Jeunemaitre
    • , Laurence Amar
    • , Hervé Lefebvre
    • , Thomas Schwarzmayr
    • , Tim M. Strom
    • , Thomas J. Jentsch
    •  & Maria-Christina Zennaro
  • Article |

    A genome-wide association study (GWAS) of 58 traits using data from the Biobank Japan Project identifies 1,407 loci, 679 of which are novel. Comparison with disease GWASs and analysis of genetic correlations and cell-type enrichment show that these clinical measurements are relevant to human disease.

    • Masahiro Kanai
    • , Masato Akiyama
    • , Atsushi Takahashi
    • , Nana Matoba
    • , Yukihide Momozawa
    • , Masashi Ikeda
    • , Nakao Iwata
    • , Shiro Ikegawa
    • , Makoto Hirata
    • , Koichi Matsuda
    • , Michiaki Kubo
    • , Yukinori Okada
    •  & Yoichiro Kamatani
  • Letter |

    Exome-wide analyses identify low-frequency coding variants associated with esophageal squamous cell carcinoma. One of the risk variants, in CYP26B1, is associated with enhanced enzymatic activity and lower levels of all-trans retinoic acid in serum.

    • Jiang Chang
    • , Rong Zhong
    • , Jianbo Tian
    • , Jiaoyuan Li
    • , Kan Zhai
    • , Juntao Ke
    • , Jiao Lou
    • , Wei Chen
    • , Beibei Zhu
    • , Na Shen
    • , Yi Zhang
    • , Ying Zhu
    • , Yajie Gong
    • , Yang Yang
    • , Danyi Zou
    • , Xiating Peng
    • , Zhi Zhang
    • , Xuemei Zhang
    • , Kun Huang
    • , Tangchun Wu
    • , Chen Wu
    • , Xiaoping Miao
    •  & Dongxin Lin

News & Comment

  • Editorial |

    The reconstruction of the genome of a woman of African ancestry from her European descendants, across eight generations, connects living people to a documented saga, drawing attention to the individuals who participated in historic events at a time when the legal, cultural and ethical implications of individual human rights began to gain currency. It is also a technical achievement that extends the methodologies for understanding our interwoven genomic and social histories.

  • News & Views |

    New genomic analyses indicate that pioneer transcription factors can sample a diverse repertoire of common binding sites among different cell types and become enriched where they cooperate with other factors specific to each cell. Pioneer-factor binding is mechanistically separate from, and is necessary for, subsequent phenomena of chromatin opening and epigenetic memory in vivo.

    • Kenneth S. Zaret
  • News & Views |

    Two new studies identify rare homozygous variants in ADCY3 that are causal for monogenic obesity in consanguineous families of Pakistani origin and are associated with increased risk of obesity in Greenlandic individuals. Greenlandic carriers of homozygous loss-of-function variants in ADCY3, and individuals from trans-ancestry studies with a burden of rare ADCY3 loss-of-function variants, also have increased risk of type 2 diabetes.

    • Inês Barroso
  • News & Views |

    Dysregulated lipid metabolism is a prominent feature of prostate cancers. Two papers in this issue identify novel genomic drivers of lipid metabolism in prostate cancer and provide implications for the subtyping and treatment of the disease.

    • Ninu Poulose
    • , Francesca Amoroso
    • , Rebecca E. Steele
    • , Reema Singh
    • , Chee Wee Ong
    •  & Ian G. Mills
  • News & Views |

    H3K4me1 is enriched at active and primed enhancers. However, whether H3K4me1 controls or simply correlates with enhancer activity and function has remained unclear. Several recent reports, including two in Nature Genetics, provide major mechanistic and functional insights into the role of H3K4me1 at enhancers.

    • Alvaro Rada-Iglesias

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