Nature Genetics - Current issue : November 2009 - Vol 41 No 11
Latest highlights
Advance online publication
Comparative analysis of Mycobacterium leprae
Article by Marc MonotStuart Cole and colleagues report genome sequences and comparative analyses of multiple strains of Mycobacterium leprae, the etiologial agent of leprosy. They define 16 sub-types of M. leprae and examine their geographical distribution.
Advance online publication
Exome sequencing
Article by Sarah NgMichael Bamshad, Jay Shendure and colleagues report the first application of exome resequencing to a mendelian disorder of unknown cause, Miller syndrome, and identify mutations in DHODH.
Advance online publication
Genetics of Parkinson's disease
Letter by Wataru SatakeTwo groups report independent genome-wide association studies of Parkinson's disease. Tatsushi Toda and colleagues investigate Parkinson's disease in the Japanese population and identify two new risk regions on 1q32 and 4p15. Andrew Singleton, Thomas Gasser and colleagues study Parkinson's disease among individuals of European ancestry and find associations at two loci, SNCA and MAPT, and provide supporting evidence for the newly discovered risk locus on 1q32.
Advance online publication
Genetics of IBD
Letter by Kouichi AsanoThree groups report independent genome-wide association studies of inflammatory bowel diseases. Michiaki Kubo and colleagues investigated ulcerative colitis in the Japanese population, the UK IBD Genetics Consortium and the Wellcome Trust Case Control Consortium 2 investigated ulcerative colitis in Europeans, and Hakon Hakonarson and colleagues investigated early-onset inflammatory bowel disease.
Advance online publication
Genetics of cisplatin ototoxicity
Letter by Colin RossColin Ross and colleagues report the association of variants in TPMT and COMT to cisplatin-induced hearing loss in children. Cisplatin is a widely used chemotherapeutic agent.
Advance online publication
ETS factors and renal morphogenesis
Article by Benson LuFrank Costantini and colleagues report the identification of the ETS transcription factors, Etv4 and Etv5, as key targets of Ret signaling during kidney branching morphogenesis.
