1600 BC
Indian texts describe fever with malaria-like symptoms.
95 BC
Lucretius suggests that a micro-organism might cause 'swamp fever'
450 AC
Oldest known source of malarial DNA.
c. 1640
Spanish colonists in South America discover quinine. The natives probably knew about it before then.
1716
Giovanni Maria Lancisi, a Roman doctor, notes that draining swamps curbs malaria. He suggests mosquitoes spread the disease, but few listen.
1880
French army surgeon Charles Louis Alfonse Laveran spots malaria parasite in blood.
1897
British doctor Ronald Ross observes malaria parasite in mosquitoes.
1934
Chloroquine discovered in Germany. Forgotten and rediscovered in 1940s.
1939-45
Second World War: the risk to soldiers prompts probably the most intense malaria research effort ever. Several new drugs discovered as a result.
1956
WHO launches global campaign to eradicate malaria.
1960s
Drug-resistant parasites and DDT-resistant mosquitoes become widespread.
1967
WHO abandons malaria eradication in favour of control.
1979
Chinese researchers describe artemisinins, a new class of malaria drug derrived from the sweet wormwood plant.
1983
First Plasmodium gene cloned. Mutation leading to drug resistance found.
1999
PATH malaria vaccine initiative founded on a $50 million grant from the Gates Foundation.
2003
2,000 children in Africa are given an experimental vaccine , RTS,S, to see how it fares in protecting against malaria.
2006
Artemisinin is synthesized in the lab for the first time, raising the prospect of cheaper, more adaptable drugs.
2006
The World Health Organisation launches an International Medical Products Anti-Counterfeiting Taskforce (IMPACT), in large part to beat back the tide of fake malarial drugs in Asia.
2007
The Bill & Melinda Gates foundation calls to eradicate malaria.
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