Depression causes a greater burden of disability than any other condition, yet it is widely undiagnosed and untreated. In this special collection of articles, Nature asks why that burden is so great, how science is helping and where research is running aground.
Chronic stress can cause depression in some individuals, but leaves others untouched. Engagement of a molecular pathway controlling the production of tiny RNA snippets might help to explain the difference.
Conventional behavioural mouse models of depression are often used to study the disorder, but cannot capture the full picture of the human disease. Here, scientists present two views about the best research strategies to adopt if treatments are to be improved. Lisa M. Monteggia, Robert C. Malenka & Karl Deisseroth
Nature sorts fact from fiction in this hot, but sometimes contentious, field: from the debate about soaring diagnoses, to the idea that scientists and engineers are at high risk of having a child with autism.
Schizophrenia is a condition experienced by over 0.5% of the world's population at some time in their lives, and has a debilitating impact on sufferers. This special issue highlights the state of play and opportunities for progress in understanding, diagnosing and treating the condition.