Almost every human protein has segments that can form amyloids, the sticky aggregates known for their role in disease. Yet cells have evolved some elaborate defences, finds Jim Schnabel.
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References
Goldschmidt, L., Teng, P. K., Riek, R. & Eisenberg, D. Proc. Natl Acad. Sci. USA 107, 3487-3492 (2010).
Dobson, C. M. Trends Biochem. Sci. 24, 329-332 (1999).
Aguzzi, A. Nature 459, 924-925 (2009).
Balbirnie, M., Grothe, R. & Eisenberg, D. S. Proc. Natl Acad. Sci. USA 98, 2375-2380 (2001).
Nelson, R. et al. Nature 435, 773-778 (2005).
Maji, S. K. et al. Science 325, 328-332 (2009).
Murray, A. N., Solomon, J. P., Wang, Y. J., Balch, W. E. & Kelly, J. W. Prot. Sci. 19, 836-846 (2010).
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Schnabel, J. Protein folding: The dark side of proteins. Nature 464, 828–829 (2010). https://doi.org/10.1038/464828a
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DOI: https://doi.org/10.1038/464828a
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