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A direct hit for thalidomide

The drug stunts limb development in zebrafish and chicks by binding to a protein called cereblon.

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References

  1. Ito, T. et al. Science 327, 1345-1350 (2010).

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  2. Therapontos, C., Erskine, L., Gardner, E. R., Figg, W. D. & Vargesson, N. Proc. Natl Acad. Sci. USA 106, 8573-8578 (2009).

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Ulrich Rüther’s website

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Fang, J. A direct hit for thalidomide. Nature (2010). https://doi.org/10.1038/news.2010.117

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