Published online 1 July 2009 | Nature 460, 19 (2009) | doi:10.1038/460019a

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Italians sue over stem cells

Government's exclusion of human embryonic cells from funding call sparks anger.

Stem-cell proponent Elisabetta Cerbai.Stem-cell proponent Elisabetta Cerbai.UNIV. FLORENCE CENTER OF MOLECULAR MEDICINE

Three scientists are appealing against the Italian government's decision to exclude human embryonic stem cells from a recent call for proposals to fund stem-cell biology.

The scientists' lawyer, Vittorio Angiolini, who specializes in bioethics and human rights, filed the appeal with Rome's administrative court on 24 June. He argues that excluding human embryonic stem cells infringes on the constitutional freedom of scientific research. The use of established lines of human embryonic stem cells in research is legal in Italy.

The original draft of the funding call did not exclude any type of stem cell. "We don't know where the sentence that was added came from," says Elisabetta Cerbai, a pharmacologist at the University of Florence who is one of the appellants. "But we suspect that a compromise deal may have been made at high political levels."

The stem-cell research fund, run by the ministry responsible for health, has a turbulent history. In 2007, the then health minister, Livia Turco, cancelled a €3-million (US$4.2-million) fund after some scientists complained that monies were being distributed without a public call for proposals and without appropriate peer review. At the time, Turco referred to the people complaining as "gangsters", but agreed to start again, with an €8-million pot and transparent reviewing procedures.

The centre-left government to which Turco belonged fell in spring last year. The following June, Turco's successor, Ferruccio Fazio, established a committee of experts to draft a call that he promised would be administered in a transparent way.

Giulio Cossu, a developmental biologist at the San Raffaele scientific institute in Milan and one of the five members of that committee, says that the group formulated a carefully worded text that would neither exclude any type of stem-cell proposal, nor incite controversy.

“Politicians should decide strategic research objectives and leave scientists to choose how best to achieve them.”


But when that text became public, a sentence had been added that explicitly excluded projects with human embryonic stem cells. It appeared online after a 26 February meeting of the State-Regions Conference, the body comprising representatives of the 20 Italian regions that decides how national health funds are distributed. "I was obviously disappointed," says Cossu, who notes that he joined the committee on the condition that there would be no exclusions based on ideology.

In media interviews at the time, Fazio dismissed rumours that the sentence had been added by someone within his ministry. He declined to comment to Nature, but in media reports has said that the sentence was added by the regions. However, the representative for Tuscany, Enrico Rossi, said publicly that no changes were made or requested when it was discussed by the conference.

Angiolini argues that "the ministry can change the text of the call only with the regions' consent".

"Our appeal is a matter of principle," says Cerbai. "Politicians should decide strategic research objectives and leave scientists to choose how best to achieve those objectives."

The other two appellants are Elena Cattaneo, a neuroscientist at the University of Milan, and Silvia Garagna, a developmental biologist at the University of Pavia. The three are financing the action with their own money.

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The case is likely to be heard by the court in the first half of July, before the funding call's closing date of 20 July.

"We expect to win," says Cerbai. But if that does not happen, they hope to take their appeal to a higher court. 

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