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Published online 17 December 2008 | Nature | doi:10.1038/news.2008.1318
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How genes are silenced
Molecular snapshot reveals the mechanics of RNA interference.
A picture of a bacterial protein complex that selects and slices up RNA molecules, thereby silencing genes, provides fresh insight into the process of RNA interference (RNAi), researchers say. The structure is the first to capture the so-called argonaute protein when it is bound to both the genetic template that guides it to its RNA target, and the target strand of RNA itself.
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