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Published online 15 October 2008 | Nature 455, 847 (2008) | doi:10.1038/455847a
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The death of microarrays?
High-throughput gene sequencing seems to be stealing a march on microarrays. Heidi Ledford looks at a genome technology facing intense competition.
Faster, cheaper DNA sequencing technology is revolutionizing the burgeoning field of personal genomics. But it is having another, more subtle effect.
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Choice of sequencing over genotyping microarray is natural if cost is not a constraint. It was only expected that reducing cost of sequencing will affect the microarray market. Most importantly, deep resequencing can only uncover rare variants.