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Published online 12 March 2008 | Nature | doi:10.1038/news.2008.667
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A protein that makes breast cancer spread
Researchers pinpoint protein 'boss' that controls gene expression.
A protein that determines whether breast cancer will spread and become deadly has been found. Researchers say that the protein, which is found inside the nuclei of cells, would be difficult and potentially dangerous to target with drugs.
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i am very very interest about this report. i want to analyse relationship between this protein and HER2/neu.
"This means that the protein could be a good prognostic test for women with breast cancer." Isn't this exactly what Genomic Health's Oncotype DX test has been doing for years???? http://www.genomichealth.com/oncotype/default.aspx
This new individually decisive protein named "Boss" is of high scientific interest, as it opens the possibility to see for its basic differences hitherto neglected by Convention (or Dogma?), like stereo-isomeric protein-confirmations with varying Isotopes of the stable sorts ²D, 13-C,18-O and of course ³T and 14-C, each of which will have signaling effects for genetically predetermined new enzyme-production and adaptive vital reactions ²D- Deuterium f.i. is known to 1.) interfere with protein-folding: used f.i. as HDX-method used to increase Protein-folding intermediates expecting re-exchange by proper iso-enzymes and 2.) to have by different Zero-energies some effects on sol/gel relation on Nano-volume-scale 3.) to affect the stability (and ease of exchanging) Hydrogen-Bonds and "stickiness"of Serum 4.) significantly to disturb the proper use of Energy (ATP-enzymes reject substrates with ²D) and so promote ADP-pathways, disturbing ATP-ADP-AMP-relation. (Similar reactions are prominent in C3 /C4 Plants-Metabolism on Enzymes discriminating against 13C entering into CoA-Enzymes transforming lipids into Glucogen & Glucose, the basis of ATP/ADP-Energy-use.) 5.) These in turn secundarily cause enzyme-activation along genetic lines which turn out as very difficult to follow if the underlying regulatives are unknown or disregarded. So secundarily Cells recording inadequate ratios of heavy organic isotopes may signalize "Lack of Energy,increase Insulin-Production!", while the signal should be read as "Lack of sufficient needed preselected adequate Substrates for genetically determined build-up of properly working Hormones, Enzymes and other signalling proteins... 6.) Deuterium-depleted Water has been shown by Hungarian researchers (Somliay et al) to have a tumor-regressive potential hitherto disregarded. Cats and dogs, however have sufficiently sensitive tastes to prefer this water if available. 7.) The Cells' abilities to generate gradients for organic heavy Isotopes in micro-compartiments of accumulation / depletion has either not been recognized or been forgotten as the Scientific Community appears to be fond of using markers way out of normal "Range of Noise" found in Nature, so that the natural "low voice-signals" tend to be cached and obscured. So promising lines of research into causes f.i. of 13-C accumulation in Colonic Polypus and Mammary-Stroma (Giese et al) were not followed up. Lyon & Baxter however showed significant gradients almost 40 years ago in this Journal, showing accumulation of 14-C even more relative to its normal scantly appearance compared to 13-C by Isotope-discrimination. 8.) These Factors may be of significance especially now, when creating new sorts of plants, under "GRAS" neglect of the vital experience of 20+ different lines developed by Nature converging in Stomata functioning well. Since 400 M a they had been allowing selection of energetically balanced ATP-ADP-AMP by using equilibrated stable & unstable organic Isotopes as food for the vertebrates and esp. Mammals co-developed since together with their adapted proteins, enzymes & iso-enzymes and Hormones and signalling hormone-like small Proteins securing healthy, longlived and fertile organisms all along the lines. 9.) If these hints have not been observed (or even deliberately been neglected) before going in for offering as Food and Fodder now substitutes for the normal C3-Products as with the new transgene Food (C3 -> C4 GMO) to an ever growing Global Population, there may be hidden Factors for Diseases just in these hidden corner-stones for borderlines, preventing hitherto undiagnosed Metabolic Disturbances of Pandemic Dimensions without sufficient Medication or NHS-Provisions. 10.) Apart from the nearsight-intended reduction of CO2 from the air, GMO as using the undiscriminating Cane- and Corn-borne genetic set-up will promote a relatively increased contents of all heavy organic isotopes including 14-C in the new fodderplants, leading to increased content in such fodder-produced Protein. This may trigger Metabolic Syndrome-like Diseases, as may already be deducted when observing Animal-Diseases in our contemporan Protein-Production in Factories for raising Avine-, Bovine and Porcine-Protein. 11.) In marine Protein-Production the Use of Recycled Animal-Protein has been used as means for differentiating Open-Sea-raised Salmon from "Farm-Fish" (Urs Luzzano 2001) 12.) Fast-growing 90-d-Rice (from PRRI), large-size & big-yield promising Australian-Sunflowers, as well as draught-resistant protein-increased Australian Wheat-bread-Wheat, oils of various transgene Plants to name only a few, apart from all known Corn-based Fodder- and Food-products are already on the Global Market and the named Safety-Context may be regarded just ventilated as "Generally to be regarded as Safe". Which just might not hold true on trying to establish the related basic energetic Problems as safe for widespread and healthy use. The Spitzbergen Dooms-Day-Vault filled with Seeds at the Command of Firms working in GMO-Business may be a sign warning against deception for liabilities. Dr.med.Klaus-J. Seelig, DTM&H Liverpool LRCM-MRCP-London, GP.emerit. Bali-Indonesia
Does this protein alone can regulate the metabolic pathways or Is it activated by some other components ? Have this protein been screened against the inhibitor ?
We've found that a SNP in this gene is actually more highly associated with colon (odds ratio 5.2) and ovarian (OR 3.5) than with breast or prostate (OR 1.2) cancers. We found no association at all with lung or pancreatic cancers. Since odds ratios roughly translate to how rate-limiting the step is for tumorigenesis, these data would suggest: 1. SATB1 will be more useful for the pre-symptomatic diagnosis of colon and ovarian cancers than breast cancer. 2. SATB1 might actually be a better target for colon and ovarian cancers than breast cancer, assuming non-toxic drugs can be found. We've actually found about 6,000 SNPs per cancer for the above 6 cancers in whites. We're very open to collaborations that protect our IP position. Best regards, Dave Moskowitz MD dwmoskowitz@genomed.com CEO, GenoMed, Inc. www.genomed.com
What about SATB1 KO mice? Do they develope metastasis?