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Published online 21 November 2007 | Nature 450, 475-477 (2007) | doi:10.1038/450475a

News Feature

Profile: Innate ability

With keen immunological insight and a knockout mouse 'factory', Shizuo Akira leads by quiet example. David Cyranoski visits the world's most-cited scientist as he prepares to run one of Japan's premier research centres.

In the spring of 2000, Osamu Takeuchi and Hiroaki Hemmi were scanning row upon row of tiny plastic wells filled with a yellow fluid. Finally they found one that had remained clear.

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