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Published online 10 October 2007 | Nature 449, 647 (2007) | doi:10.1038/449647a
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Doubts raised over stem-cell marker
Protein may not be accurate in adult samples.
Two papers published this week challenge the validity of using the protein Oct4 as a marker for adult stem cells. The protein maintains embryonic stem cells in an undifferentiated state, called pluripotency, but the papers question whether it has the same function in adult stem cells.
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