Mutations could make recent tuberculosis vaccines less powerful than older ones.
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References
Brosch R., et al. Proc. Nat. Acad. Sci. USA, published early online, doi:10.1073/pnas.0700869104 (2007).
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Ledford, H. Old vaccines may be better than new. Nature (2007). https://doi.org/10.1038/news070312-2
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DOI: https://doi.org/10.1038/news070312-2