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Published online 17 March 2006 | Nature | doi:10.1038/news060313-17

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Tragic drug trial spotlights potent molecule

Study reveals risks of interfering with immune system.

Researchers are trying to explain how a prototype drug that manipulates the immune system triggered devastating side effects in a British clinical trial.

The trial shot into headlines earlier this week when all six patients who took an experimental antibody fell rapidly and severely ill.

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