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Published online 16 March 2005 | Nature | doi:10.1038/news050314-8

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DNA gets a fake fifth base

Artificial sequences could one day answer questions about evolution.

One of the first things any biology student learns is that DNA, the recipe for life, is written with four letters. But what if you could add extra ones? Researchers who have managed to build, and replicate, DNA with an ersatz fifth letter are on their way to finding out.

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