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Published online 6 October 2004 | Nature | doi:10.1038/news041004-9
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Molecular kiss of death
Chemistry Nobel winners unmasked how proteins are destroyed in cells.
Three researchers who unravelled the mechanism behind a molecular kiss of death - a tag that marks proteins for destruction - have been awarded this year's Nobel Prize in Chemistry.
Irwin Rose of the University of California, Irvine, together with Aaron Ciechanover and Avram Hershko from the Israel Institute of Technology in Haifa, transformed cell biology during the early 1980s through their studies of how proteins are broken down inside cells.
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