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Published online 18 July 2003 | Nature | doi:10.1038/news030714-15

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Gene length predicts depression risk

Some people are hit harder by stressful life events than others.

Variation in a single gene may explain why some people weather stressful events while others are plunged into depression, say scientists.

The gene, which encodes a protein called 5-HTT, reveals its influence when people experience divorce, debt, unemployment or other occasions of "threat, loss, humiliation or defeat", Terrie Moffitt of King's College London and her colleagues have shown.

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