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Published online 18 October 2002 | Nature | doi:10.1038/news021014-12
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Out of place prions trash cells
Faulty rubbish disposal may be behind mad cow disease and CJD.
A malfunctioning waste-disposal system may be behind the neurodegenerative diseases scrapie, mad cow disease (BSE) and their human counterpart Creutzfeldt-Jakob disease (CJD). A mouse cell study now suggests that nerves die when tiny amounts of misshapen prion protein are left too long in the wrong place1.
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