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Published online 12 July 2002 | Nature | doi:10.1038/news020708-17
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Chemical synthesis of poliovirus cDNA: Generation of infectious virus in the absence of natural template
First ever virus synthesized from chemicals alone.
Using genetic code as the recipe and carbon-containing chemicals as ingredients, researchers have made infective poliovirus entirely from scratch. This is the first time that a working biological entity has been made using chemistry alone.
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