Newts grow new legs, Hydra new heads. These remarkable creatures may hold clues for researchers developing human cellular therapies. But the connections are only now starting to be made. Helen Pearson reports.
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References
Kato, K., Orii, H., Watanabe, K. & Agata, K. Dorsal and Ventral Positional Cues Required for the Onset of Planarian Regeneration May Reside in Differentiated Cells. Dev. Biol 233, 109 - 121 (2001).
Hobmayer, B. et al. WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra. Nature 407, 186 - 189 (2000).
Technau, U. et al. Parameters of self-organization in Hydra aggregates . Proc. Natl Acad. Sci. USA 97, 12127 - 12131 (2000).
Smith, K. M., Gee, L. & Bode, H. R. HyAlx, an aristaless-related gene, is involved in tentacle formation in hydra. Development 127, 4743 - 4752 (2000).
Guachat, D. et al. Evolution of Antp-class genes and differential expression of Hydra Hox/paraHox genes in anterior patterning . Proc. Natl Acad. Sci. USA 97, 4493 - 4498 (2000).
Aldhous, P. Can they rebuild us? Nature 410, 622 - 625 (2001).
Rosania, G. R. et al. Myoseverin, a microtubule-binding molecule with novel cellular effects. Nature Biotechnology 18, 304 - 308 (2000).
Odelberg, S. J., Kollhoff, A. 7 Keating, M.T. Dedifferentiation of mammalian myotubes induced by msx1. Cell 103, 1099 - 1109 (2000).
Velloso, C. P., Simon, A. & Brockes, J. P. Curr. Biol 11, 855 - 858 (2001).
McGann, C. J., Odelberg, S. J. & Keating, M. T. Proc. Natl Acad. Sci. USA 98, 13699 - 13704 (2001).
Clark, L. D., Clark, R. K. & Heber-Katz, E. A New Murine Model for Mammalian Wound Repair and Regeneration. Clin. Immunol. Immunopathol 88, 35 - 45 (1998).
Leferovich, J. M. et al. Heart regeneration in adult MRL mice. Proc. Natl Acad. Sci. USA 98, 9830 - 9835 (2001).
McBrearty, B. A., Clark, L. D., Zhang, X.-M., Blankenhorn, E. P. & Heber-Katz, E. Genetic analysis of a mammalian wound-healing trait. Proc. Natl Acad. Sci. USA 95, 11792 - 11797 (1998).
Sanchez Alvarado, A. & Newmark, P. A. Double-stranded RNA specifically disrupts gene expression during planarian regeneration. Proc. Natl Acad. Sci. USA 96, 5049 - 5054 (1999).
Bosch, T. C. G. & Fujisawa, T. Polyps, peptides and patterning. BioEssays 23, 420 - 427 (2001).
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University of UtahHarvard Medical School
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Pearson, H. The regeneration gap. Nature (2001). https://doi.org/10.1038/news011122-14
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DOI: https://doi.org/10.1038/news011122-14