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Published online 13 April 2001 | Nature | doi:10.1038/news010419-1

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Sweet success for bitter tonic

Chemists have synthesized the antimalarial drug quinine after 150 years of trying.

David Livingstone called quinine "the most constipating of drugs". But without this extract of the cinchona tree which puts the bitter bite in tonic water he would probably have succumbed to malaria much sooner than he did.

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