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Published online 21 June 2000 | Nature | doi:10.1038/news000622-8

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New research shows how St John's Wort, a popular herbal remedy for depression, may change the way the human body deals with other drugs.

In 1994 alone, Germans took 66 million doses of a drug that is legal, requires no prescription and has never been subjected to large scale clinical trials. The drug has a 2,400 year history in folk medicine -- it is the herb St John's Wort or hypericum perforatum.

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