Latest Research

  • Article |

    How entorhinal grid cells control hippocampal coding and behavior remains elusive. The authors report that increasing the spatial scale of grid cells expands the scale and reduces the stability of place fields, impairing spatial memory in mice.

    • Caitlin S. Mallory
    • , Kiah Hardcastle
    • , Jason S. Bant
    •  & Lisa M. Giocomo
  • Technical Report |

    dCas9-mediated activation has been verified and widely used in vitro. Here the authors generated a potent in vivo activation platform and applied it to control the transcription of multiple genetic elements in the mammalian brain.

    • Haibo Zhou
    • , Junlai Liu
    • , Changyang Zhou
    • , Ni Gao
    • , Zhiping Rao
    • , He Li
    • , Xinde Hu
    • , Changlin Li
    • , Xuan Yao
    • , Xiaowen Shen
    • , Yidi Sun
    • , Yu Wei
    • , Fei Liu
    • , Wenqin Ying
    • , Junming Zhang
    • , Cheng Tang
    • , Xu Zhang
    • , Huatai Xu
    • , Linyu Shi
    • , Leping Cheng
    • , Pengyu Huang
    •  & Hui Yang
  • Article |

    A salt-rich diet promotes cerebrovascular diseases and dementia. This study shows that high dietary salt in mice induces a TH17 response in the gut leading to cerebral endothelial dysfunction and cognitive impairment via circulating IL-17.

    • Giuseppe Faraco
    • , David Brea
    • , Lidia Garcia-Bonilla
    • , Gang Wang
    • , Gianfranco Racchumi
    • , Haejoo Chang
    • , Izaskun Buendia
    • , Monica M. Santisteban
    • , Steven G. Segarra
    • , Kenzo Koizumi
    • , Yukio Sugiyama
    • , Michelle Murphy
    • , Henning Voss
    • , Joseph Anrather
    •  & Costantino Iadecola
  • Article |

    Using a genetic approach, Wang et al. demonstrate an essential function for m6A mRNA modification in promoting neural stem cell proliferation and reveal interactions between m6A and histone modification as a novel gene regulatory mechanism.

    • Yang Wang
    • , Yue Li
    • , Minghui Yue
    • , Jun Wang
    • , Sandeep Kumar
    • , Robert J. Wechsler-Reya
    • , Zhaolei Zhang
    • , Yuya Ogawa
    • , Manolis Kellis
    • , Gregg Duester
    •  & Jing Crystal Zhao
  • Brief Communication |

    fMRI activity in human entorhinal cortex is modulated by eye-movement direction with 60° periodicity, implicating a grid cell-like code in mapping visual space. This suggests a role for entorhinal grid coding in cognition beyond spatial navigation.

    • Matthias Nau
    • , Tobias Navarro Schröder
    • , Jacob L. S. Bellmund
    •  & Christian F. Doeller
  • Article |

    The brain is a complex biological machine that results from the birth, migration and differentiation of neurons. This paper reports that Vps15 enables the migration and survival of neurons, and implicates the gene in neurodevelopmental disease.

    • Thomas Gstrein
    • , Andrew Edwards
    • , Anna Přistoupilová
    • , Ines Leca
    • , Martin Breuss
    • , Sandra Pilat-Carotta
    • , Andi H. Hansen
    • , Ratna Tripathy
    • , Anna K. Traunbauer
    • , Tobias Hochstoeger
    • , Gavril Rosoklija
    • , Marco Repic
    • , Lukas Landler
    • , Viktor Stránecký
    • , Gerhard Dürnberger
    • , Thomas M. Keane
    • , Johannes Zuber
    • , David J. Adams
    • , Jonathan Flint
    • , Tomas Honzik
    • , Marta Gut
    • , Sergi Beltran
    • , Karl Mechtler
    • , Elliott Sherr
    • , Stanislav Kmoch
    • , Ivo Gut
    •  & David A. Keays
  • Brief Communication |

    The authors show that human entorhinal cortex supports a grid cell-like representation of visual space. This visual grid pattern is stably anchored to the external visual world in a fashion analogous to rodent grid representations of navigable space.

    • Joshua B. Julian
    • , Alexandra T. Keinath
    • , Giulia Frazzetta
    •  & Russell A. Epstein
  • Article |

    In mice, stress-induced priming of glutamate synapses in the PVN can be transmitted through social interactions. This requires PVN CRH neuron activation in both of the interacting mice and release of an alarm pheromone from the stressed mouse.

    • Toni-Lee Sterley
    • , Dinara Baimoukhametova
    • , Tamás Füzesi
    • , Agnieszka A. Zurek
    • , Nuria Daviu
    • , Neilen P. Rasiah
    • , David Rosenegger
    •  & Jaideep S. Bains
  • Article |

    Pathological TDP-43 protein aggregates are a hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. TDP-43 pathology alters the morphology of nuclear pore complexes and cause deficits in nucleocytoplasmic transport.

    • Ching-Chieh Chou
    • , Yi Zhang
    • , Mfon E. Umoh
    • , Spencer W. Vaughan
    • , Ileana Lorenzini
    • , Feilin Liu
    • , Melissa Sayegh
    • , Paul G. Donlin-Asp
    • , Yu Han Chen
    • , Duc M. Duong
    • , Nicholas T. Seyfried
    • , Maureen A. Powers
    • , Thomas Kukar
    • , Chadwick M. Hales
    • , Marla Gearing
    • , Nigel J. Cairns
    • , Kevin B. Boylan
    • , Dennis W. Dickson
    • , Rosa Rademakers
    • , Yong-Jie Zhang
    • , Leonard Petrucelli
    • , Rita Sattler
    • , Daniela C. Zarnescu
    • , Jonathan D. Glass
    •  & Wilfried Rossoll
  • Review Article |

    Polanía, Nitsche and Ruff summarize the state of non-invasive brain stimulation research in humans, discuss some current debates about properties and limitations of these methods, and give recommendations for how these challenges may be addressed.

    • Rafael Polanía
    • , Michael A. Nitsche
    •  & Christian C. Ruff
  • Article |

    Assessing person-level human brain maps across 18 fMRI studies, the authors identify separable representations of pain, cognitive control, and negative emotion in the medial frontal cortex that generalize across different studies and tasks.

    • Philip A. Kragel
    • , Michiko Kano
    • , Lukas Van Oudenhove
    • , Huynh Giao Ly
    • , Patrick Dupont
    • , Amandine Rubio
    • , Chantal Delon-Martin
    • , Bruno L. Bonaz
    • , Stephen B. Manuck
    • , Peter J. Gianaros
    • , Marta Ceko
    • , Elizabeth A. Reynolds Losin
    • , Choong-Wan Woo
    • , Thomas E. Nichols
    •  & Tor D. Wager
  • Perspective |

    The glial scar plays critical but divergent roles during regeneration of the mammalian CNS. Here the authors propose that in-depth analysis of the functionally heterogeneous populations of reactive glia within the scar is needed to fully understand the glial scar’s dual nature.

    • Katrina L. Adams
    •  & Vittorio Gallo
  • Brief Communication |

    A genome-wide association study of delay discounting (DD) on 23,127 subjects found that genotype accounted for 12% of variance in DD; the DD genetic signature overlapped with ADHD, schizophrenia, depression, smoking, personality, cognition and weight.

    • Sandra Sanchez-Roige
    • , Pierre Fontanillas
    • , Sarah L. Elson
    • , Anita Pandit
    • , Ellen M. Schmidt
    • , Johanna R. Foerster
    • , Gonçalo R. Abecasis
    • , Joshua C. Gray
    • , Harriet de Wit
    • , Lea K. Davis
    • , James MacKillop
    •  & Abraham A. Palmer
  • Resource |

    Using single-cell RNA-sequencing, the authors record snapshots of the dynamic sensory-experience-dependent transcriptome across all cell types of the visual cortex in mice exposed to a light stimulus. The authors note diverse cell-type-specific programs in pyramidal neuron subtypes and robust non-neuronal responses that may regulate experience-dependent neurovascular coupling and myelination.

    • Sinisa Hrvatin
    • , Daniel R. Hochbaum
    • , M. Aurel Nagy
    • , Marcelo Cicconet
    • , Keiramarie Robertson
    • , Lucas Cheadle
    • , Rapolas Zilionis
    • , Alex Ratner
    • , Rebeca Borges-Monroy
    • , Allon M. Klein
    • , Bernardo L. Sabatini
    •  & Michael E. Greenberg
  • Article |

    The authors investigate grid cell dynamics after removal of a border between two environments. Near the transition between environments, grid fields changed location, resulting in local spatial periodicity and continuity between the original maps.

    • Tanja Wernle
    • , Torgeir Waaga
    • , Maria Mørreaunet
    • , Alessandro Treves
    • , May-Britt Moser
    •  & Edvard I. Moser
  • Article |

    Grid cell activity may subserve path integration, but a direct link is lacking. The authors selectively disrupt retro-hippocampal region grid cell activity and show that disrupted grid cell firing impairs performance in a path integration task.

    • Mariana Gil
    • , Mihai Ancau
    • , Magdalene I. Schlesiger
    • , Angela Neitz
    • , Kevin Allen
    • , Rodrigo J. De Marco
    •  & Hannah Monyer
  • Article |

    Long-lasting synaptic plasticity is regarded as a mechanism for learning and memory. Using genetically engineered mice in which the C-terminal domains of AMPA receptor subtypes are switched, the authors reveal that GluA1 and GluA2 differentially regulate synaptic plasticity and contribute to different forms of learning.

    • Zikai Zhou
    • , An Liu
    • , Shuting Xia
    • , Celeste Leung
    • , Junxia Qi
    • , Yanghong Meng
    • , Wei Xie
    • , Pojeong Park
    • , Graham L. Collingridge
    •  & Zhengping Jia
  • Article |

    The authors show that Munc13-1 molecules form multiple supramolecular self-assemblies that serve as vesicular release sites. Having multiple Munc13-1 assemblies affords a stable synaptic weight, which confers robustness of synaptic computation.

    • Hirokazu Sakamoto
    • , Tetsuroh Ariyoshi
    • , Naoya Kimpara
    • , Kohtaroh Sugao
    • , Isamu Taiko
    • , Kenji Takikawa
    • , Daisuke Asanuma
    • , Shigeyuki Namiki
    •  & Kenzo Hirose
  • Brief Communication |

    The authors live-image zebrafish myelin sheath Ca2+ activity in vivo and find that high-amplitude long-duration Ca2+ transients precede calpain-dependent sheath retractions while frequent low-amplitude short-duration transients drive sheath growth.

    • Marion Baraban
    • , Sigrid Koudelka
    •  & David A. Lyons