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The axon guidance receptor Plexin-B1 regulates the cellular interaction of peri-plaque astrocytes with microglia to affect the pathophysiology of Alzheimer’s disease.
Oligodendrocyte-lineage NG2 glia are shown to limit prion-induced neurodegeneration by quenching toxic microglial responses. Their depletion unleashes prostaglandin E2 secretion by microglia and contributes non-cell-autonomously to prion toxicity.
Intersectional adeno-associated viruses are important for neuroscience research but can be limited by complex and bulky design parameters. Hughes et al. present a unique and space-saving approach that simplifies toolkit development and provides expanded functionality.
This paper presents Simple Behavioral Analysis (SimBA), an open-source platform for automated, explainable machine learning analysis of behavior. SimBA comes with extensive documentation, a graphical interface and an active community and works with any organism tracked by pose estimation.
How the brain tracks blood glucose dynamics is unclear. Viskaitis et al. show that hypothalamic orexin/hypocretin cells track glucose concentration and rate of change and that their activity is important for glucose-evoked locomotor suppression.
LINE-1 retrotransposons are a type of mobile DNA element normally repressed in the body. Here the authors show that LINE-1 sequences can jump in mouse parvalbumin interneurons and also promote the transcription of key parvalbumin interneuron genes.
Mature myelin has been considered static, though recent evidence indicates it is in fact dynamic. Here, Osso and Hughes review the dynamics of mature myelin, a form of neuroplasticity, from myelin turnover to remodeling of myelin structure. The authors consider the mechanisms that regulate these dynamics and the functional implications of mature myelin remodeling.
By using genetic admixture in the multi-omic analysis of postmortem brains from Black Americans, we show that genetic ancestry influences gene expression in the brain. Notably, we find enrichment of ancestry-associated genes for immune response and vascular function, but not neuronal function. Our findings have potential implications for stroke, Parkinson’s disease and Alzheimer’s disease.
The increased inclusion of samples from individuals from minoritized communities in biomedical research will help to mitigate health disparities that stem from a medical enterprise founded in racism and exclusion. In this issue of Nature Neuroscience, Benjamin et al. investigate how genetic ancestry influences the expression of genes in the brain, an effort supported by community leaders who raised funding, partnered in shaping research questions and had a central role in the interpretation and communication of the study’s findings. Here, we outline the public and social context that motivated these efforts towards ensuring equitable access to the benefits of science for all.
Studying gene expression in admixed Black Americans, Benjamin et al. reveal genetic ancestry-linked differences impacting immune and vascular genes and potentially influencing neurological disease risk. These findings highlight the importance of considering ancestry in brain research.
The circuit mechanisms underlying emotion recognition are unclear. Here, Dautan et al. show a role for a long-range feedback loop comprising somatostatin inhibitory projections from the medial prefrontal cortex (mPFC) to the retrosplenial cortex (RSC) and excitatory feedback projections from the RSC to the mPFC.
Christenson et al. describe hue-selective neurons in the fruit fly optic lobe. Using a connectomics-constrained model combined with genetic manipulations of the circuit, they show that recurrent connections are critical for hue selectivity.
It has been widely believed that a key function of sleep is to actively clear metabolites and toxins from the brain. Miao, Luo et al. show in mice that brain clearance is markedly reduced—not increased—during sleep and anesthesia.
Physiologically relevant stimulation of dopamine neurons does not function as a reward and does not endow cues with a reward representation. However, high-frequency stimulation is represented as a sensory-specific goal that motivates behavior.
The subcommissural organ (SCO) is a gland in the brain, and relatively little is known about its function. Zhang et al. genetically ablated SCO cells and observed severe hydrocephalus and neuronal defects. The reintroduction of SCO-derived peptides into SCO-ablated brain substantially rescued developmental defects.
Brain tissue from patients with focal cortical dysplasia type II (FCDII) exhibits dysmorphic neurons bearing hallmarks of senescence. Treatment with a senolytic drug reduces seizures in an FCDII preclinical mouse model.
Neural activity does not always lie in a low-dimensional subspace. The authors extend this classic view to show that task-relevant information is distributed across multiple covariability classes and propose a new method, sliceTCA, to disentangle them.