C-terminal modulator controls Ca²⁺-dependent gating of Ca_v1.4 L-type Ca²⁺ channels

Anamika Singh, Daniel Hamedinger, Jean-Charles Hoda, Mathias Gebhart, Alexandra Koschak, Christoph Romanin & Jörg Striessnig

Supplementary Fig. 1 (pdf 580K)
Sequence alignment of C-terminal tails of neuronal Ca_v1 L-type channels.

Supplementary Fig. 2 (pdf 112K)
Comparison of K1591X channels containing 2a or 3 subunits.

Supplementary Fig. 3 (pdf 100K)
Inactivation properties of Ca_v 1.4_C122.

Supplementary Fig. 4 (pdf 76K)
Ca²⁺ dependence of C₁₂₂-CFP binding to peptide YFP-PreIQ-IQ-PostIQ in intact HEK-293 cells.

Supplementary Fig. 5 (pdf 48K)
Potential molecular mechanism for CDI modulation by C₁₂₂.

Supplementary Methods (pdf 116K)

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