Nature Neuroscience
- 9, 1088 - 1089 (2006)
doi:10.1038/nn0906-1088
Huntingtin's critical cleavageJohn D Fryer & Huda Y Zoghbi
John Fryer and Huda Zoghbi are in the Department of Neuroscience and the Department of Molecular and Human Genetics, Program in Developmental Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA.
Correspondence should be addressed to Huda Y Zoghbi hzoghbi@bcm.tmc.edu The early pathogenic events leading to neurodegeneration in Huntington disease are not clear. A recent paper shows that mutating a caspase-6 cleavage site in the huntingtin protein is sufficient to prevent pathogenesis.
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