Nature Neuroscience
- 9, 1081 - 1083 (2006)
doi:10.1038/nn0906-1081
TREKing toward new antidepressantsJoshua A Gordon1 & Rene Hen21
Joshua A. Gordon is in the Department of Psychiatry, Columbia University, and at the New York State Psychiatric Institute, New York, New York 10032, USA. 2
Rene Hen is in the Departments of Pharmacology and Psychiatry, and at the Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA.
Correspondence should be addressed to Joshua A Gordon jg343@columbia.edu or Rene Hen rh95@columbia.edu Mice lacking the background potassium channel TREK-1 show elevated activity of serotonergic neurons and behave as if they have been treated with an antidepressant drug, reports a new study. This suggests that the TREK-1 channel may be a good target for the development of drugs for the treatment of depression.
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