Microglia are thought to contribute to neurodegeneration. Now ablating the receptor for the chemokine fractalkine is shown to increase microglial inflammatory response and neuronal death in vivo in several models of CNS insult.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Fractalkine Induces Hepcidin Expression of BV-2 Microglia and Causes Iron Accumulation in SH-SY5Y Cells
Cellular and Molecular Neurobiology Open Access 06 June 2019
-
Dual effects of noradrenaline on astroglial production of chemokines and pro-inflammatory mediators
Journal of Neuroinflammation Open Access 09 July 2013
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Gao, H.M., Liu, B., Zhang, W. & Hong, J.S. Trends Pharmacol. Sci. 24, 395–401 (2003).
Cardona, A.E. et al. Nat. Neurosci. 9, 917–924 (2006).
Harrison, J.K. et al. Proc. Natl. Acad. Sci. USA 95, 10896–10901 (1998).
Maciejewski-Lenoir, D., Chen, S., Feng, L., Maki, R. & Bacon, K.B. J. Immunol. 163, 1628–1635 (1999).
Meucci, O., Fatatis, A., Simen, A.A. & Miller, R.J. Proc. Natl. Acad. Sci. USA 97, 8075–8080 (2000).
Bazan, J.F. et al. Nature 385, 640–644 (1997).
Hundhausen, C. et al. Blood 102, 1186–1195 (2003).
Mizuno, T., Kawanokuchi, J., Numata, K. & Suzumura, A. Brain Res. 979, 65–70 (2003).
Meucci, O. et al. Proc. Natl. Acad. Sci. USA 95, 14500–14505 (1998).
Jung, S. et al. Mol. Cell. Biol. 20, 4106–4114 (2000).
Dauer, W. & Przedborski, S. Neuron 39, 889–909 (2003).
Gurney, M.E. et al. Science 264, 1772–1775 (1994).
Liberatore, G. et al. Nat. Med. 5, 1403–1409 (1999).
Wu, D.C. et al. Proc. Natl. Acad. Sci. USA 100, 6145–6150 (2003).
Teupser, D. et al. Proc. Natl. Acad. Sci. USA 101, 17795–17800 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bérangère Ré, D., Przedborski, S. Fractalkine: moving from chemotaxis to neuroprotection. Nat Neurosci 9, 859–861 (2006). https://doi.org/10.1038/nn0706-859
Issue Date:
DOI: https://doi.org/10.1038/nn0706-859
This article is cited by
-
Fluoxetine Decreases Phagocytic Function via REV-ERBα in Microglia
Neurochemical Research (2023)
-
Persistent Acidic Environment Induces Impaired Phagocytosis via ERK in Microglia
Neurochemical Research (2022)
-
Serum fractalkine and 3-nitrotyrosine levels correlate with disease severity in Parkinson’s disease: a pilot study
Metabolic Brain Disease (2022)
-
Fractalkine Induces Hepcidin Expression of BV-2 Microglia and Causes Iron Accumulation in SH-SY5Y Cells
Cellular and Molecular Neurobiology (2019)
-
Fractalkine Over Expression Suppresses α-Synuclein-mediated Neurodegeneration
Molecular Therapy (2015)