Nature Neuroscience 9, 870 - 872 (2006)
Published online: 18 June 2006; | doi:10.1038/nn1718
Amygdala BDNF signaling is required for consolidation but not encoding of extinctionJasmeer P Chhatwal1, 2, Lisa Stanek-Rattiner1, 2, Michael Davis1, 2
& Kerry J Ressler1, 21
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, Georgia 30322, USA. 2
Center for Behavioral Neuroscience, Yerkes Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA.
Correspondence should be addressed to Kerry J Ressler kressle@emory.edu Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of conditioned fear. Whereas TrkB.t1-infected rats showed normal within-session extinction, their retention of extinction was impaired, suggesting that amygdala TrkB activation is required for the consolidation of stable extinction memories.
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated.
|