Nature Neuroscience 9, 870 - 872 (2006)
Published online: 18 June 2006; | doi:10.1038/nn1718
Amygdala BDNF signaling is required for consolidation but not encoding of extinctionJasmeer P Chhatwal1, 2, Lisa Stanek-Rattiner1, 2, Michael Davis1, 2
& Kerry J Ressler1, 21
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, Georgia 30322, USA. 2
Center for Behavioral Neuroscience, Yerkes Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA.
Correspondence should be addressed to Kerry J Ressler kressle@emory.edu Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of conditioned fear. Whereas TrkB.t1-infected rats showed normal within-session extinction, their retention of extinction was impaired, suggesting that amygdala TrkB activation is required for the consolidation of stable extinction memories.
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