Nature Neuroscience 9, 859 - 861 (2006)
doi:10.1038/nn0706-859
Fractalkine: moving from chemotaxis to neuroprotectionDiane Bérangère Ré
& Serge Przedborski
The authors are in the Departments of Neurology, Pathology and Cell Biology, and at the Center for Motor Neuron Biology and Disease, BB-302, Columbia University, 650 West 168th Street, New York, New York 10032, USA. sp30@columbia.edu
Microglia are thought to contribute to neurodegeneration. Now ablating the receptor for the chemokine fractalkine is shown to increase microglial inflammatory response and neuronal death in vivo in several models of CNS insult.
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