Abstract
Disruption of overt circadian rhythms can occur without influencing the endogenous pacemaker, the so-called 'masking' effect classically elicited by light. As the physiological pathways involved in light masking remain elusive, we analyzed mice lacking the dopamine D2 receptor. Although circadian rhythmicity was normal, D2R-null mice showed a markedly deficient light masking response, indicating that D2R-mediated signaling is an essential component of the neuronal pathways leading to light masking of circadian rhythms.
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Acknowledgements
M.D. is supported by Japan Society for the Promotion of Science Postdoctoral Fellowships for Research Abroad; I.Y. by a fellowship from the Association pour la Recherche sur le Cancer; and J.H. by a fellowship from the Fondation pour la Recherche Médicale. This work and M.M. and E.T. were supported by the EC LSHM-CT-2004-005166 grant. Additional funds are from Fondation de France, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire Régional, Fondation de la Recherche Médicale, Université Louis Pasteur, Electricité de France, Association pour la Recherche sur le Cancer and La Ligue Contre le Cancer.
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Supplementary information
Supplementary Fig. 1
Light induction of mPer1 is reduced in the retina of D2R knock-out mice. (PDF 189 kb)
Supplementary Fig. 2
Generation of a specific antibody against D2R. (PDF 270 kb)
Supplementary Fig. 3
Immunofluorescence showing the localisation of the D2 Receptor in the mouse retina. (PDF 587 kb)
Supplementary Fig. 4
Photic induction of mPer1 in the SCN. (PDF 187 kb)
Supplementary Fig. 5
Visually-driven behaviors of D2R−/− mice. (PDF 199 kb)
Supplementary Table 1
Phenotypic characteristics of D2R knock-out mice (PDF 69 kb)
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Doi, M., Yujnovsky, I., Hirayama, J. et al. Impaired light masking in dopamine D2 receptor–null mice. Nat Neurosci 9, 732–734 (2006). https://doi.org/10.1038/nn1711
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DOI: https://doi.org/10.1038/nn1711
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