Table of contents


cover image
Top

Editorial

New competition in Germany p711

doi:10.1038/nn0606-711


Top

Obituary

Mircea Steriade 1924–2006 p713

György Buzsáki & Denis Paré

doi:10.1038/nn0606-713


Top

News and Views

How inflammation promotes regeneration pp715 - 717

Marie T Filbin

doi:10.1038/nn0606-715

Macrophages near neuronal cell bodies can promote regeneration in an otherwise inhibitory environment. Now Yin et al. identify oncomodulin as a factor secreted from macrophages that promotes extensive regeneration of lesioned optic nerve axons when applied together with elevated cyclic AMP (cAMP) and mannose.

See also: Article by Yin et al.


Chalk one up for 'nature' during neocortical neurogenesis pp717 - 718

Ken-ichi Mizutani & Nicholas Gaiano

doi:10.1038/nn0606-717

During development, neurons destined for different neocortical layers are sequentially generated. Shen et al. report that this timing is programmed within individual progenitor cells and depends mainly on cell-intrinsic mechanisms.

See also: Article by Shen et al.


Biochemical confinements without walls in aspiny neurons pp719 - 720

Pablo E Castillo & Kamran Khodakhah

doi:10.1038/nn0606-719

Dendritic spines confine activity-dependent changes to the affected synapses. A paper in this issue reports that retarded diffusion in dendrites of aspiny interneurons may create dendritic biochemical compartments without spines.

See also: Article by Soler-Llavina & Sabatini


The stuff dreams are made of: anatomical substrates of REM sleep pp721 - 722

Jerome M Siegel

doi:10.1038/nn0606-721

Exactly how animals switch between different sleep states remains unknown. A new study in Nature provides a glimpse into the mechanisms and anatomy of the brain regions that trigger rapid eye movement sleep.


More neurons may not make you smarter p722

Kalyani Narasimhan

doi:10.1038/nn0606-722

See also: Brief Communication by Meshi et al.


Top

Brief Communications

Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment pp729 - 731

Dar Meshi, Michael R Drew, Michael Saxe, Mark S Ansorge, Denis David, Luca Santarelli, Chariklia Malapani, Holly Moore & René Hen

doi:10.1038/nn1696

See also: News and Views by Narasimhan


Impaired light masking in dopamine D2 receptor–null mice pp732 - 734

Masao Doi, Irene Yujnovsky, Jun Hirayama, Monica Malerba, Emanuele Tirotta, Paolo Sassone-Corsi & Emiliana Borrelli

doi:10.1038/nn1711


BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex pp735 - 737

Jeffrey A Kleim, Sheila Chan, Erin Pringle, Kellan Schallert, Vincent Procaccio, Richard Jimenez & Steven C Cramer

doi:10.1038/nn1699




Top

Articles

The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells pp743 - 751

Qin Shen, Yue Wang, John T Dimos, Christopher A Fasano, Timothy N Phoenix, Ihor R Lemischka, Natalia B Ivanova, Stefano Stifani, Edward E Morrisey & Sally Temple

doi:10.1038/nn1694

See also: News and Views by Mizutani & Gaiano


Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis pp752 - 760

Victor Anggono, Karen J Smillie, Mark E Graham, Valentina A Valova, Michael A Cousin & Phillip J Robinson

doi:10.1038/nn1695


Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O pp761 - 769

Takafumi Shintani, Masaru Ihara, Hiraki Sakuta, Hiroo Takahashi, Ikuko Watakabe & Masaharu Noda

doi:10.1038/nn1697



Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain pp779 - 786

Hiroyuki Koizumi, Holden Higginbotham, Tiffany Poon, Teruyuki Tanaka, Brendan C Brinkman & Joseph G Gleeson

doi:10.1038/nn1704


Midline radial glia translocation and corpus callosum formation require FGF signaling pp787 - 797

Karen Müller Smith, Yasushi Ohkubo, Maria Elisabetta Maragnoli, Mladen-Roko Rašin, Michael L Schwartz, Nenad Šestan & Flora M Vaccarino

doi:10.1038/nn1705




Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo pp816 - 823

Xiaohai Wang, Nanhong Lou, Qiwu Xu, Guo-Feng Tian, Wei Guo Peng, Xiaoning Han, Jian Kang, Takahiro Takano & Maiken Nedergaard

doi:10.1038/nn1703


Palmitoylation of huntingtin by HIP14is essential for its trafficking and function pp824 - 831

Anat Yanai, Kun Huang, Rujun Kang, Roshni R Singaraja, Pamela Arstikaitis, Lu Gan, Paul C Orban, Asher Mullard, Catherine M Cowan, Lynn A Raymond, Renaldo C Drisdel, William N Green, Brinda Ravikumar, David C Rubinsztein, Alaa El-Husseini & Michael R Hayden

doi:10.1038/nn1702


RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion pp832 - 842

Jun Ding, Jaime N Guzman, Tatiana Tkatch, Songhai Chen, Joshua A Goldberg, Philip J Ebert, Pat Levitt, Charles J Wilson, Heidi E Hamm & D James Surmeier

doi:10.1038/nn1700


Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells pp843 - 852

Yuqin Yin, Michael T Henzl, Barbara Lorber, Toru Nakazawa, Tommy T Thomas, Fan Jiang, Robert Langer & Larry I Benowitz

doi:10.1038/nn1701

See also: News and Views by Filbin


Top